Principal Scientist/Associate Director

Job Description

Job DescriptionDescription:

Principal Scientist/Associate Director, Bioanalytical

Sciences

Palo Alto, CA

About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough

therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio,

originally carved out in 2024 after securing $300M in private financing from external investors.

GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and

deliver transformative medicines to treat patients who suffer from genetic diseases.

Who You Are

You are a bioanalytical scientist with deep, hands-on experience developing and validating

assays for oligonucleotide therapeutics — and the strategic mindset to translate that expertise

into high-quality data packages that advance programs from discovery through IND filing and

into the clinic. You understand what it takes to oversee CROs with rigor: you write precise study

designs, ask the right scientific questions during protocol review, and hold external partners

accountable to timelines and data quality. You are as comfortable discussing hybrid-ELISA

method development for a siRNA candidate as you are reviewing an LC-MS/MS bioanalytical

report or a PK data package from a rodent biodistribution study.

We are looking for someone whose core experience sits at the intersection of oligonucleotide

bioanalysis and CRO-based drug development programs. The ideal candidate has:

• Designed and validated bioanalytical methods for oligonucleotides across preclinical

and/or clinical matrices — including plasma, tissue, urine, and CSF

• Deep practical experience with assay platforms relevant to oligonucleotide PK/PD: LC-

MS/MS, hybrid-ELISA, MSD ECL, qPCR, and/or NGS-based approaches

• Managed CRO relationships across the full lifecycle of bioanalytical programs: from

method development through sample analysis, data review, and final report

• Contributed to IND-enabling bioanalytical packages and is fluent in relevant regulatory

guidance (FDA BMV, EMA BMV, and/or ICH M10)

• Experience with conjugated oligonucleotides (GalNAc-siRNA, antibody-oligo conjugates,

or similar) as a strong differentiator

Key Responsibilities

Bioanalytical Strategy & Assay Oversight

• Define bioanalytical strategy for oligonucleotide programs, including platform selection,

matrix prioritization, and fit-for-purpose method development plans

• Oversee CRO partners executing method development, validation, and sample analysis;

provide scientific direction, protocol review, and data package review• Evaluate assay performance data critically — selectivity, sensitivity, precision, accuracy,

matrix effects, stability — and drive resolution of technical issues

• Ensure bioanalytical deliverables align with study timelines and regulatory requirements

for IND filings and ongoing clinical programs

PK/PD Sample Analysis & Data Interpretation

• Oversee analysis of PK, biodistribution, and PD samples from preclinical studies,

including multi-tissue oligonucleotide quantitation

• Integrate bioanalytical data with DMPK and pharmacology outputs to support exposure-

response and candidate selection decisions

• Review and interpret bioanalytical reports, identify data gaps, and recommend follow-up

studies as needed

Regulatory & Documentation

• Contribute to IND-enabling bioanalytical packages, method validation summaries, and

related regulatory documents

• Ensure bioanalytical programs adhere to GLP requirements where applicable and to

relevant BMV guidance

• Maintain clear, audit-ready documentation standards across CRO-generated data and

internal records

Cross-Functional Collaboration

• Partner with DMPK, translational science, and clinical pharmacology teams to align on

sample collection requirements, assay timelines, and data interpretation

• Serve as the internal subject matter expert on oligonucleotide bioanalysis —

communicating assay capabilities, limitations, and data quality considerations to cross-

functional stakeholders

• Provide scientific oversight and mentorship to junior team members and

sourcing/coordination staff supporting bioanalytical activities

Preferred Education & Experience

• Ph.D. in analytical chemistry, biochemistry, pharmacology, or a related field; or

equivalent advanced degree with commensurate industry experience

• 7+ years (PS) / 10+ years (AD) of industry experience in bioanalytical sciences, with

direct experience supporting oligonucleotide (siRNA and/or ASO) drug development

programs

• Demonstrated expertise in oligonucleotide bioanalytical methods: LC-MS/MS, hybrid-

ELISA, MSD ECL, and/or qPCR across diverse biological matrices

• Track record of managing CRO partners on bioanalytical method development,

validation, and sample analysis programs

• Familiarity with FDA BMV, EMA BMV, and/or ICH M10 regulatory guidance and GLP

requirements as applied to bioanalytical programs• Prior contribution to one or more IND submissions, including bioanalytical method

validation summaries or supporting PK/PD data packages

• Strong data review, scientific communication, and cross-functional collaboration skills

Nice-to-Haves

• Direct experience with conjugated oligonucleotides (GalNAc-siRNA, antibody-oligo

conjugates, or ligand-based delivery platforms)

• Familiarity with biomarker assay development or translational PD endpoints relevant to

oligonucleotide programs

• Experience supporting Phase 1 clinical bioanalytical programs, including bridging

strategies from preclinical to clinical matrices

• Chinese Mandarin language proficiency (spoken and/or written)

• Prior experience in a lean, fast-moving biotech environment

No Matter Your Role at GondolaBio, Successful Team Members Are

• Patient Champions, who put patients first and uphold strict ethical standards.

• Entrepreneurial Operators, who drive toward practical solutions and have an ownership

mindset.

• Truth Seekers, who are detailed, rational, and humble problem solvers.

• Individuals Who Inspire Excellence in themselves and those around them.

• High-quality executors, who execute against goals and milestones with quality,

precision, and speed.

What We Offer

• Patient Days, where we are fortunate to hear directly from individuals living with the

conditions we are seeking to impact throughout the year and learn how we can improve

our efforts.

• A culture inspired by our values: put patients first, think independently, be radically

transparent, every minute counts, and let the science speak.

• An unyielding commitment to always putting patients first.

• A decentralized model that enables our program teams to focus on advancing science

and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put

decision-making power in the hands of those closest to the science.

• A place where you own the vision — both for your program and your own career path.

• A collaborative, fast-paced, data-driven environment where we inspire ourselves and

each other to always perform at the top of our game.

• Access to learning and development resources to help you get in the best professional

shape of your life.

• Robust and market-competitive compensation & benefits package (Base, Performance

Bonus, Equity, health, welfare & retirement programs).

• Flexible PTO.• Rapid career advancement for strong performers.

• Potential ability to work on multiple GondolaBio Pharma programs across multiple

therapeutic areas over time.

• Partnerships with leading institutions.

• Commitment to Diversity, Equity & Inclusion.

The base pay range for this position for the United States is $175,000 to $215,000 per year.

The actual compensation offered will be determined based on a number of job-related factors,

including experience, skills, qualifications, and location. A bonus plan and equity will also be

offered.

Requirements: