Job Description
Job Description
Job Title: Computational Scientist
Location: South San Francisco CA 94080
Duration: 12 Months
Description:
Computational Scientist (contract): Human Genetics, gRED
The Human Genetics department at Genentech is seeking a highly independent computational scientist with a strong hands-on analytical background in genetic epidemiology, statistical genetics, or computational biology, to develop and apply analytical approaches to integrate and interpret genetic, genomic, and clinical data. We are particularly interested in candidates with skill sets that position them to tackle the integration of multiple sources of human biological data, such as whole genome sequencing and single cell RNA-Seq/ATAC-Seq data, including knowledge of emerging multimodal data integration methods.
This will be a full time contract position for 1 year from date of hire, with the possibility of extension. This is available either as a hybrid or remote position and would ideally be based in a US-friendly time zone.
Responsibilities:
Collaborate with scientists in Human Genetics department to analyze large datasets of genetic, genomic, and clinical data from internal studies (including our clinical trials and high throughput screens), collaborations with academic and industry partners, and public external data sets
Develop analytical approaches to integrate and interpret these data, delivering insights into disease biology to propel our translational goals
Implement novel machine learning algorithms to understand associations between imaging and omics data
Coordinate the intake and preparation of new datasets as they become available for analysis
Document process, findings, and code
Present findings to the department and cross-functional collaborators and contribute to publications
Requirements:
Extensive experience in large-scale genetic/genomic data analysis including one or more of the following areas of expertise:
Understanding of principles of genetic epidemiology
Association analysis with array- and sequence-based genetic data (GWAS - genome-wide association studies) on human data
Analysis of sequence-based molecular assay data (eg RNA-Seq) including differential expression methods, single-cell sequencing data (eg scRNA-Seq, scATAC-Seq) and/or proteomic data
Integration of genetic and molecular data for multimodal analyses
PhD (or Masters with significant experience) in Statistical Genetics, Computational Biology, Bioinformatics, Genetic Epidemiology, or a related field
Fluent in R, Python, and shell scripting. Some familiarity with C++ will be a plus
Experience working with git and high performance computing (e.g. the SLURM scheduling manager)
Curiosity and desire to learn more about human genetics, bioinformatics, and biology
Ability to produce high-quality analysis results with minimal supervision. This includes meeting key deadlines and making sensible independent decisions
Good communication skills and experience working as part of a team