Mass Spectrometry Automation Engineer / Scientist

Synectics Inc

South San Francisco, CA, USA

Published: 6/14/2022

Science

Full Time

Job Description

Job description

Discovery Biotherapeutics and Genetic Medicine (BGM) at is seeking a highly motivated scientist to join the Biotherapeutics group at the Bay Area (ABA) site in South San Francisco.
This role offers a unique opportunity to contribute to various Discovery Research Therapeutic Areas (TAs) and projects by providing production and analytical characterization of biologics and biopharmaceutical products, such as monoclonal antibodies, multi-specifics, and other antibody-like formats.
As part of our team, your work will drive the discovery and development of next generation biologics through production and interrogation of protein attributes.
Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, and subunit approaches.
Ensure the optimal functioning of LC/MS equipment through routine maintenance and effective troubleshooting.
Design and execute production of biotherapeutic proteins to external CRO vendors, provide guidance on desired product quality attributes, then deliver the results of the production to our therapeutic partners.
Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.
Collaborates with MS experts across our Research & Development Division to assess and implement new bioanalytical technology.
Independently and autonomously perform laboratory research and method development with minimal supervision, demonstrating high productivity and scientific initiative

Qualifications:

BS, MS, or PhD in chemistry, biochemistry, or related discipline with typically 7+ (BS), 5+ (MS), or 0+ (PhD) years of relevant experience.
Demonstrated hands-on expertise with various mass spectrometry platforms, including Waters Xevo G2-XS QToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.
Proficiency in data processing and bioinformatic and statistical workflows (e.g., Protein Metrics, Biosphere, Waters Connect, UNIFI)
Proven experience in the application of LC/MS analyses for interrogation of monoclonal antibodies, multispecific biologics, and protein therapeutics to provide sequence verification, post-translational modification, desired/expected chain pairing, and identity of DLP profile.
Experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions.
Experience with chromatography and purification systems (protein A/G, AEX, SEC, mixed-mode with AKTA systems), and analytical instruments (Agilent HPLC, Waters UPLC and LC/MS, CE-SDS, SDS-PAGE) is a plus
Goal-oriented team player with excellent verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast-paced, multidisciplinary environment.

California Fair Chance Act:

Synectics Inc. will consider qualified applicants with a criminal history pursuant to the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if Synectics Inc. is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. Find out more about the Fair Chance Act by visiting calcivilrights.ca.gov/fair-chance-act/.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins.

Synectics is an equal opportunity employer.

\nCompany Description

Synectics is a leading staffing and workforce solutions company dedicated to connecting exceptional talent with top organizations. We specialize in IT, engineering, finance, healthcare, and professional services recruitment, offering both contract and permanent staffing solutions. With a people-first approach, we focus on understanding the unique needs of our clients and candidates to create long-term, successful matches. Our mission is to empower businesses with the right talent while helping professionals achieve rewarding career opportunities