Job Description
Job Description
Job Title: Scientist-LNP Formulation
Location: San Diego, CA 92111 (Onsite)
Duration: 03+ Month Contract
Pay Rate: 47 $/hr. On W2
Job Summary
We are seeking a motivated and detail-oriented Scientist I to join the Formulation team in San Diego, CA. This is a hands-on laboratory position focused on the formulation and optimization of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery.
The ideal candidate will have at least 2 years of hands-on LNP formulation experience, including encapsulation of nucleic acids such as mRNA, siRNA, or DNA. The candidate should be comfortable working in a laboratory environment, analyzing experimental data, and collaborating with senior scientists and cross-functional teams.
Key Responsibilities
- Formulate and optimize lipid nanoparticles (LNPs) and targeted LNPs (tLNPs) for nucleic acid delivery.
- Perform nucleic acid encapsulation for mRNA, siRNA, DNA, and related applications.
- Execute Design of Experiments (DoE) studies to evaluate LNP compositions and processing parameters.
- Characterize LNP formulations using techniques such as Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
- Analyze, interpret, and present experimental data to the formulation team.
- Collaborate with cross-functional teams to support formulation requests and research activities.
- Support downstream formulation activities, including cryoprotection, scale-up, and stability studies, as needed.
- Maintain accurate and detailed laboratory records and experimental documentation.
- Support routine laboratory activities including inventory management, supply ordering, buffer preparation, and autoclaving.
- Work under the guidance of senior formulation scientists while maintaining high standards for data quality and reproducibility.
Required Qualifications
- Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related scientific discipline with 4+ years of biopharmaceutical industry experience; OR
- Master’s degree in a relevant discipline with 1+ years of industry experience.
- Minimum 2 years of hands-on laboratory experience in LNP formulation.
- Hands-on experience with nucleic acid encapsulation, including mRNA, siRNA, or DNA.
- Experience with LNP characterization techniques, particularly:
-
- Dynamic Light Scattering (DLS)
- Zeta potential
- Ribogreen assays
- Strong proficiency with Microsoft Excel for data analysis and presentation.
- Strong attention to detail and ability to generate reproducible experimental data.
- Excellent organizational, communication, and teamwork skills.
- Ability to work effectively in a fast-paced laboratory environment.
Preferred Qualifications
- Experience with targeted LNP (tLNP) formulation.
- Experience preparing mAb-, Fab-, ScFv-, or VHH-coated LNPs.
- Experience with immune-cell delivery.
- Experience using JMP, GraphPad Prism, or similar statistical/data analysis software.
- Experience with DoE-based formulation screening and optimization.
- Experience with LNP scale-up, stability, or cryoprotection studies.
\nCompany Description
LanceSoft is rated as one of the largest staffing firms in the US by SIA. Our mission is to establish global cross-culture human connections that further the careers of our employees and strengthen the businesses of our clients. We are driven to use the power of our global network to connect businesses with the right people, and people with the right businesses without bias. We provide Global Workforce Solutions with a human touch.
Company Description
LanceSoft is rated as one of the largest staffing firms in the US by SIA. Our mission is to establish global cross-culture human connections that further the careers of our employees and strengthen the businesses of our clients. We are driven to use the power of our global network to connect businesses with the right people, and people with the right businesses without bias. We provide Global Workforce Solutions with a human touch.